Title: Cellink BIO X Advanced Multi-Material 3D Bioprinting System for Cancer Biology and Organoid Research
Subject: Title: Cellink BIO X Advanced Multi-Material 3D Bioprinting System for Cancer Biology and Organoid ResearchSolicitation Number: 75N98026Q01018CELLINKNCI09639Notice Type: PRESOLNAICS: 541714Set-Aside: No Set aside usedNotice Published: 08-15-26Response Due: 08-15-26Agency: Department of Health and Human ServicesOffice: NATIONAL INSTITUTES OF HEALTHContact: Vishnuvajjala Hanumanth Rao This email address is being protected from spambots. You need JavaScript enabled to view it.Office Address: BETHESDA, MD 20892Place of Performance: Bethesda, MD 20892
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THE LABORATORY INVESTIGATES MECHANISMS FO TUMORS INITIATIONS PROGRESSION AND THERAPEUTIC RESPONSE USING ADVANCED THREE DIMENSIONAL(3d) CULTURE SYSTEMS ORGANID MODELS AND ENGINEERED TISSUE MICRONMENTS . CURRENT RESEARCH FOCUESES ON UNDERSTANDING INTERACTIONS BETWEEN TUMORS CELLS AND THERI SURROUNDING STROMAL AND EXTRACULLULAR MATRIX ENVIRONMENTS THAT INFLUENCE CANCER DEVELOPMENT AND TREATMENT RESPONSE. EXISTING LABORATORY METHODS FOR GENERATING 3D TISSUEMODELS RELYON MANUAL PREPRATION TECHNIQUES THAT INTRODUCE VARIABILITY IN CONSTRUCT GEOMETRY, CELL DISTRUBUTION, AND EXTRACELLULAR MATRIX COMPOSITION. THESE LIMITATIONS REDUCE EXPERIMENTAL REPRODUCIBILITY AND RESTRICT THE COMPLEXITY OF TISSUE MODELS THAT CAN BE GENERATED. TO SUPPORT ONGOING NIH-FUNDED RESEARCH, THEMUTHUSWAMY LABORATORY REQUIRES A HIGH-PRECISION 3DE BIOPRINTING PLATFORM CAPABLE OF REPRODUCIBLY FABRICATING MULTICELLULAR TISSUE CONSTRUCTS USING A VARIETY OF BIOMARKS AND BIOMATERIALS. THE SYSTEM MUST INTEGRATE WITH EXISTING CELL CULTURE, MICROSCOPY, AND DOWNSTREAM MOLECULAR ANALYSIS WORKFLOWS WHILE ENABLING STANDARDIZED PRODUCTION OF PHYSIOLOGICALLY RELEVENT INVITRO MODELS.